Covid-19 infection mechanisms

Scientists are exchanging information around the globe.  I’ve heard anecdotal accounts of how patients  have seemed to be improving, and then suddenly have a turn for the worse.  The link below has a pretty good explanation for this.   The immune  system, according to the article below, designed to defend the body against invaders, can kick into overdrive and act  in a harmful manner (cytokine storm).  Children with a less developed immune system might not have this immune reaction hence they have more mild symptoms.  Thank God!

I think I’ll stop here, as it is better explained in the article below.

Stay tuned and safe,

Dave

Link:

https://www.bloomberg.com/news/articles/2020-04-16/your-risk-of-getting-sick-from-covid-19-may-lie-in-your-genes?sref=MKhnhvyR

The Pullout of the World Health Organization is a Terrible Decision

Covid-19 is frightening and the human toll of Covid-19 already  is staggering: 134,000 people around the world succumb to the disease.  They died alone generally unable to breath. How high the death toll goes is uncertain.   Almost every country in the world lost lives to this virus.

What could be worse?  Every medical professional standing next to Trump knows the answer.  The CDC knows the answer.    Tuberculosis,   AIDS and malaria, really in that order.   Tuberculosis accounts for 1.2 to 1.4 million deaths in 2018.  It is present in urban areas of developing countries.   The 2018 estimate of HIV related deaths is 770,000.  For Malaria, in 2018, it is 405,000 deaths.  Malaria is deadly to children under 5 years old, as 262,000 children died of malaria (67% of the total).  In Africa, they say that average life expectancy is meaningless  as the big trick in life is getting past age 5.  Incredibly sad.

So, infectious diseases are ravaging the lives of the youngest and oldest in our society.  If one survives to age 5, the next challenge will be getting past 60.  Particularly bad in parts of the world where health services are just not available.

The World Health Organization allies with other countries to fight against infectious diseases, and public health issues regardless of politics.  It recognizes that the African countries, like Nigeria, where malaria is rampant, already was in a health crisis before the arrival of Covid-19.      World Health Organization is uniting efforts to find cures and vaccines for these infectious diseases.

And the World Health Organization is making progress, particularly against tuberculosis which is generally curable and preventable.  There are new challenges with drug resistant strains.

The current preventative measures, such as social distancing, closing schools and businesses and blocking international travel are only temporary measures.   And trying to isolate the US from the rest of the world is impossible without extreme economic consequences.

We absolutely need foundations like the Bill and Melinda Gates Foundation and the World Health Organizations working with health organizations in making our planet healthier.  We need cures and vaccines developed  through scientific cooperation.  Trump’s defunding WHO,  I hope, will  last only until November 2020, when we have a new president.   The  WHO isn’t perfect, but he is using it as a  distraction and scapegoat to the US problems with mess created when the CDC test kit debacle.  See NYT article.

We are “stronger together” and we need to restore our real leadership in the world.  It is time to increase global awareness- not isolate ourselves from the rest of the world.

Covid-19 is not a US problem.  It is a global problem.

A healthier planet = a healthier US.

Stay tuned and stay safe,

Dave

Links:

New York Times Opinion

Wikipedia: Tuberculosis 

World Health Organization

WHO:  Malaria

 

 

 

End of Covid-19

The disease won’t be gone until it is eradicated everywhere.  I could say this 100 times, and to some, it really won’t sink in.

Zero new cases in New York, Madrid, Moscow, New Delhi and Baghdad. It means the day the persons with symptoms are immediately tested, and isolated. If a vaccine is developed, it has to be applied globally.    That’s why we have the World Health Organization,  Doctors without Borders and many more international organizations.   The IMF, G-7 or G-20 will also be critical on how to transition from lockdown to more relaxed rules.

I’m so tired of hearing that it is the fault of China and/or the WHO, that we have it here.   After flights from China were canceled, flights were continuing from the real hot spots, namely Italy and Spain.  US travelers in Europe and China were, whenever possible, cutting short their trips to get away from the virus hotspots and were obvious disease vectors.   There will be plenty of time later for everyone to determine what we could or should have done to prevent the spread of Covid-19.  But it’s in 151 countries now, and it is a worldwide crisis.

Stay tuned,

Dave

 

Covid-19 increases and decreases

It’s terrible to see Covid-19 exponentially increasing in many countries.  An exponential curve means the number of infected to double in a specific number of days.  If doubling occurs every 2 days we go 1 – 2 – 4 – 8 in 8 days. We’ve seen worse with Covid-19 go from 100 to 1000 in a span of 8 days.   The hope is with all precautionary actions, including frequent hand washing and social distancing, the rate of increase (acceleration)  will be less than exponential and will transition to linear.  The disease is at a stable point for health officials when more people are leaving the hospital than entering it.   The disease is in decline phase only when there is a negative trend in new cases. The fact that the disease is less than exponential in many countries, is good news, but the rate of growth is still very high and still at crisis levels.

For the data to be accurate and to prevent a premature lifting of measures, there must be testing available on demand to anyone.   I have high hopes that the US and all countries will increase their testing.  I fear a second wave, as some scientists have warned.

Stay tuned and safe.

Dave

Coronavirus Origins

Coronavirus came from an animal, most likely a bat in China.  It is positively of animal origin,  based on a number of papers from distinguished scientific organizations, such as Scripps Institute. Apparently the scientists can tell the difference.

It was not made in the US in some secret lab.  Nor was it made in China in one of their secret labs.

If you hear Tucker Carlson on Fox News, spreading this idiotic conspiracy nonsense, just turn the channel.

Links:

Scripps Institute

USA Today 

 

Go Abbott, Elon, and Gilead

Some strong positives in the war against Covid-19:

Abbott

Abbott came out with their 5 to 13 minute toaster size molecular  point-of-care Covid-19 test.  It received emergency approval from FDA.   In layman terms, the virus is opened using reagents, then the released genetic material is replicated so even extremely small amounts can be detected.   Abbott is said to be ramping up production.  I would love to see this toaster at the drive-thru testing facilities.

Gov. Phil Murphy announced at his daily COVID-19 briefing on Tuesday afternoon that Bergen County, New Jersey will be the site for a new rapid test from Abbott Laboratories.

Elon Musk

How did Musk get 1225 ventilators so quickly, when the federal government couldn’t:  “China had an oversupply, so we bought 1255 FDA-approved ResMed, Philips & Medtronic ventilators on Friday night & airshipped them to LA,” Musk said on Twitter.   I’m sure patients and hospitals couldn’t give a damn about where these ventilators were sourced.

Gilead

Gilead is conducting limited clinical trials on their drug, remdesivir, in China.  Per their  Gilead website:  “The limited preclinical data on remdesivir in MERS and SARS indicate that remdesivir may have potential activity against COVID-19.   Remdesivir is an experimental medicine that does not have established safety or efficacy for the treatment of any condition. ”  It is being referred to in the media as the Ebola drug.  It is hope to slow or block the virus replication once in a healthy cell.    Gilead hopes to have results of clinical studies by the end of April.

Stay tuned and stay healthy,

Dave

Links:

Gilead story 

The other stories are very easy to find with a Google search.